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DNA BASE MODIFICATIONS IN NEURAL PLASTICITY AND NEUROPSYCHIATRIC DISORDERS

神经可塑性和神经精神疾病中的 DNA 碱基修饰

基本信息

批准号：
9116944
负责人：
Marcelo Andres Wood
金额：
$ 29.89万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-15 至 2018-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9116944
关键词：
8-hydroxyguanosine Adaptive Behaviors Address Adult Area Base Excision Repairs Behavioral Bioinformatics Chromatin Cognitive Complementary DNA DNA DNA Double Strand Break DNA Modification Process DNA Repair Pathway Development Environment Epigenetic Process Eukaryota Exposure to Frequencies Fright Future Gene Expression Gene Expression Regulation Gene Targeting Genome Genomic DNA Genomics Guanine Health Heterogeneity Knowledge Learning Light Longevity Memory Mitotic Modification Molecular Mutagens Nature Neurodegenerative Disorders Neuronal Plasticity Neurons Oxidative Stress Pattern Population Pre-Clinical Model Process Protocols documentation Research Role Stimulus Technology Testing Therapeutic Therapeutic Intervention Thinking Tissues Toxin Work age related anxiety-related disorders base biological systems bisulfite carcinogenesis cell type epigenetic regulation experience gel electrophoresis gene function innovation insight irradiation neuropsychiatric disorder new technology novel oxidation pressure research study response targeted treatment

项目摘要

DESCRIPTION (provided by applicant): Although epigenetic regulation of gene expression has been shown to be associated with experience- dependent neural plasticity and memory formation, due to technical and conceptual limitations, the full repertoire of DNA base modifications and their role in neuropsychiatric disease remains equivocal. In this project, new technology will be developed to more precisely identify activity-dependent epigenetic mechanisms in neuronal populations selectively activated by learning and challenge current concepts related to the full repertoire of DNA base modifications and their role in regulating gene expression. Specifically, we will determine whether there is a causal relationship between various DNA base modifications and rapid behavioral adaptation, and we will advance the state of knowledge regarding the molecular mechanisms underlying the memory in a preclinical model of fear-related anxiety disorder.

描述（由申请人提供）：尽管基因表达的表观遗传调节已显示与经验依赖性神经可塑性和记忆形成相关，但由于技术和概念上的限制，DNA碱基修饰的全部谱及其在神经精神疾病中的作用仍然不明确.在该项目中，将开发新技术，以更精确地识别通过学习选择性激活的神经元群体中的活性依赖性表观遗传机制，并挑战与DNA碱基修饰及其在调节基因表达中的作用相关的完整库的当前概念。具体来说，我们将确定各种DNA碱基修饰和快速行为适应之间是否存在因果关系，我们将推进关于恐惧相关焦虑症临床前模型中记忆的分子机制的知识状态。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Persistent variations in neuronal DNA methylation following cocaine self-administration and protracted abstinence in mice.

DOI：
10.1016/j.nepig.2015.10.001
发表时间：
2015-10
期刊：
Neuroepigenetics
影响因子：
0
作者：
Baker-Andresen D;Zhao Q;Li X;Jupp B;Chesworth R;Lawrence AJ;Bredy T
通讯作者：
Bredy T

Evolving insights into RNA modifications and their functional diversity in the brain.

DOI：
10.1038/nn.4378
发表时间：
2016-09-27
期刊：
NATURE NEUROSCIENCE
影响因子：
25
作者：
Nainar, Sarah;Marshall, Paul R.;Tyler, Christina R.;Spitale, Robert C.;Bredy, Timothy W.
通讯作者：
Bredy, Timothy W.

Cognitive neuroepigenetics: the next evolution in our understanding of the molecular mechanisms underlying learning and memory?

认知神经表观遗传学：我们对学习和记忆分子机制理解的下一步发展？