Role of Fibroblasts in Axon Regeneration after SCI
成纤维细胞在 SCI 后轴突再生中的作用
基本信息
- 批准号:9110307
- 负责人:
- 金额:$ 33.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2012
- 资助国家:美国
- 起止时间:2012-09-01 至 2017-07-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAcuteAddressAnimal ModelAnimalsAxonBiologyBlood VesselsChronicCicatrixClinicalCollagenContusionsDepositionDura MaterElectron MicroscopyExtracellular MatrixFibroblastsFunctional disorderGeneticGoalsGreen Fluorescent ProteinsHumanInjuryKnowledgeLocationMapsMeningealMeningesModelingMorphologyMusNatural regenerationPatientsPatternPericytesPharmacologyPlatelet-Derived Growth Factor ReceptorPopulationReceptor SignalingRecovery of FunctionReporterRodentRoleSiteSourceSpinal CordSpinal cord injurySpinal cord injury patientsTestingTherapeuticTimeTissuesTransgenic Miceaxon regenerationcell typeclinical applicationdiphtheria toxin receptordisabilityin vitro Assayin vivonew therapeutic targetnovelpromoterspatiotemporaltargeted treatmenttheories
项目摘要
DESCRIPTION (provided by applicant): Spinal cord injury (SCI) results in formation of scar tissue that is a potent barrier to axon regeneration. This scar is comprised of excess deposition of extracellular matrix (ECM) molecules in both rodents and humans. Why most axons fail to grow into this ECM-rich region is not fully understood. In vitro assays have implicated fibroblasts
as a major source of inhibitory ECM molecules, but whether this also true in vivo is not clear. While the meninges were thought to be the primary source of fibroblasts after SCI, recent evidence indicates that the perivascular niche could be an alternative source of the scar tissue. The overall goal of this proposal is to determine the role of perivascular fibroblasts in scar formation in order to promote axon regeneration after contusive SCI by pursuing the following aims: 1) Determine the temporospatial distribution and the cellular fate of fibroblasts after contusive SCI 2) Determine the effect of fibroblast ablation on scar formation and axon regeneration after SCI. 3) Determine the role of fibroblast PDGFR-� on scar formation and axon regeneration after SCI. Our proposed studies will fill a gap in knowledge about the role of fibroblasts in animal models of SCI and may reveal new therapeutic targets to treat SCI patients.
描述(由申请人提供):脊髓损伤(SCI)导致瘢痕组织的形成,这是轴突再生的有力障碍。这种疤痕是由啮齿类动物和人类细胞外基质(ECM)分子的过量沉积组成的。为什么大多数轴突不能生长到这个富含ecm的区域还不完全清楚。体外实验表明与成纤维细胞有关
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jae K Lee其他文献
Single drug biomarker-based prediction of response and survival for ER-negative breast cancer patients treated with combination chemotherapy
基于单一药物生物标志物的 ER 阴性乳腺癌联合化疗患者的反应和生存预测
- DOI:
- 发表时间:
- 期刊:
- 影响因子:3.9
- 作者:
yongzi chen;youngchul Kim;Hatem H.Soliman;guoguang ying;Jae K Lee - 通讯作者:
Jae K Lee
Transcription profiling of CD4+ T cells in rhesus macaques that infected with simian‐human immunodeficiency virus and re‐challenged with SIVmac251
感染猿猴人类免疫缺陷病毒并用 SIVmac251 重新攻击的恒河猴中 CD4+ T 细胞的转录谱
- DOI:
10.1111/jmp.12185 - 发表时间:
2015 - 期刊:
- 影响因子:0.7
- 作者:
Hye;C. Pise;Annamalai Muthiah;M. Radonovich;Eun Mi Lee;Jae K Lee;R. Pal - 通讯作者:
R. Pal
Jae K Lee的其他文献
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{{ truncateString('Jae K Lee', 18)}}的其他基金
Regeneration-permissive glia after spinal cord injury
脊髓损伤后允许再生的神经胶质细胞
- 批准号:
10286370 - 财政年份:2021
- 资助金额:
$ 33.47万 - 项目类别:
RAP as a therapeutic compound for neuronal regeneration after spinal cord injury
RAP 作为脊髓损伤后神经元再生的治疗化合物
- 批准号:
8898661 - 财政年份:2014
- 资助金额:
$ 33.47万 - 项目类别:
RAP as a therapeutic compound for neuronal regeneration after spinal cord injury
RAP 作为脊髓损伤后神经元再生的治疗化合物
- 批准号:
8781972 - 财政年份:2014
- 资助金额:
$ 33.47万 - 项目类别:
Translational Profile of Perivascular Fibroblasts after Spinal Cord Injury
脊髓损伤后血管周围成纤维细胞的转化概况
- 批准号:
8607220 - 财政年份:2013
- 资助金额:
$ 33.47万 - 项目类别:
Translational Profile of Perivascular Fibroblasts after Spinal Cord Injury
脊髓损伤后血管周围成纤维细胞的转化概况
- 批准号:
8489438 - 财政年份:2013
- 资助金额:
$ 33.47万 - 项目类别:
Targeting lipid clearance pathways to promote repair after SCI
靶向脂质清除途径促进 SCI 后修复
- 批准号:
9512063 - 财政年份:2012
- 资助金额:
$ 33.47万 - 项目类别:
Targeting lipid clearance pathways to promote repair after SCI
靶向脂质清除途径促进 SCI 后修复
- 批准号:
9979952 - 财政年份:2012
- 资助金额:
$ 33.47万 - 项目类别:
Targeting lipid clearance pathways to promote repair after SCI
靶向脂质清除途径促进 SCI 后修复
- 批准号:
10677106 - 财政年份:2012
- 资助金额:
$ 33.47万 - 项目类别:
Targeting Lipid Clearance Pathways to Promote Repair After SCI
针对脂质清除途径促进 SCI 后修复
- 批准号:
10227001 - 财政年份:2012
- 资助金额:
$ 33.47万 - 项目类别:
Role of Fibroblasts in Axon Regeneration after SCI
成纤维细胞在 SCI 后轴突再生中的作用
- 批准号:
8702255 - 财政年份:2012
- 资助金额:
$ 33.47万 - 项目类别:
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