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Testosterone and Cortisol Levels in Infant Health and Development

婴儿健康和发育中的睾酮和皮质醇水平

基本信息

批准号：
9113358
负责人：
JUNE I CHO
金额：
$ 33.89万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-01 至 2017-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9113358
关键词：
Affect Age Age-Months Alabama Amniotic Fluid Apgar Score Behavioral Biochemical Biological Factors Biological Markers Birth Birth Weight Blood Body mass index Brain Characteristics Clinic Cognitive Collaborations Collection Data Data Analyses Development Early identification Education Endocrinologist Equation Exhibits Female Future Gender Gestational Age Goals Growth Health Hormonal Hormones Hydrocortisone Immune Infant Infant Development Infant Health Intervention Laboratory Research Language Language Development Lead Linear Models Longitudinal Studies Marital Status Measurement Measures Methods Mission Modeling Mothers Motor National Institute of Child Health and Human Development Neonatal Neonatal Intensive Care Units Neurologic Newborn Infant Outcome Outcome Study Perinatal Premature Infant Race Recruitment Activity Research Research Design Risk Role Saliva Schedule Socialization Source System Testosterone Time Umbilical Cord Blood Universities Update Very Low Birth Weight Infant Videotape Visit Woman base comparative design early childhood experience fetal blood follow-up gender difference health data infancy infant outcome infant temperament insight male neonate outcome prediction premature psychologic theories therapy development

项目摘要

DESCRIPTION: Identification of early markers for negative health outcomes is critical to maintaining optimal infant development and for developing successful health interventions, particularly for very low birth weight (VLBW, birth weight less than 1,500 g) preterm male infants who are more prone to health-related problems than female infants. General gender-difference theories and the extreme male brain theories, as well as our preliminary studies suggest that testosterone and cortisol levels are positively related to each other in infants and are negatively associated with infant health outcomes in early infancy and with developmental outcomes between ages 1 to 3. We plan to confirm that testosterone rather than cortisol is a more reliable marker/predictor of complications affecting infants' health outcomes, mother-infant interactions, and infant cognitive/motor/ language developmental outcomes; and that male infants exhibit a higher sensitivity to testosterone levels than female infants as evidenced by these outcomes. This study involves a comparative and longitudinal research design aimed at describing gender differences measured by testosterone and cortisol levels with (1) health outcomes of neonates and infants, (2) quality of mother-infant interactions, and (3) infant cognitive/motor/language development after adjusting for maternal psychological state, infant temperament, and characteristics of mothers. One hundred ninety mother-VLBW preterm infant pairs will be recruited from the neonatal intensive care unit (NICU) at the University of Alabama at Birmingham affiliated Women and Infants Center. Demographic and health data of the pairs will be collected at the NICU and updated at the newborn follow-up clinic where the infants are scheduled for three follow-up visits (at 6, 12, and 24 months corrected age for prematurity) following discharge. During these visits, mother-infant interactions will be videotaped for 15 min and infant cognitive/motor/language developmental outcomes will be collected using age-appropriate measurements. Concurrent and repeated measurement of testosterone and cortisol levels both in infants and in mothers will be conducted through infancy and early childhood (at birth, 40 weeks postmenstrual age and 6 , 12 , and 24 months corrected age). Exploratory data analysis will first be performed to gain insight into the collected data. Generalized linear models will be used to model independent data with one time collection while the generalized estimating equation and the generalized linear mixed-effects models are standard approaches for modeling correlated longitudinal data.

描述：识别负面健康结果的早期标志物对于维持最佳婴儿发育和制定成功的健康干预措施至关重要，特别是对于出生体重极低（VLBW，出生体重低于 1,500 克）的早产男婴，他们比女婴更容易出现健康相关问题。一般性别差异理论和极端男性大脑理论以及我们的初步研究表明，婴儿时期睾酮和皮质醇水平呈正相关，反之呈负相关。与婴儿早期的婴儿健康结果以及 1 至 3 岁之间的发育结果相关。我们计划确认睾酮而不是皮质醇是影响婴儿健康结果、母婴互动和婴儿认知/运动/语言发育结果的并发症的更可靠的标记/预测因子；这些结果证明，男婴比女婴对睾酮水平表现出更高的敏感性。本研究涉及比较和纵向研究设计，旨在描述通过睾酮和皮质醇水平测量的性别差异，包括（1）新生儿和婴儿的健康结果，（2）母婴互动的质量，以及（3）调整母亲心理状态、婴儿气质和母亲特征后的婴儿认知/运动/语言发展。将从阿拉巴马大学伯明翰分校附属妇女和婴儿中心的新生儿重症监护病房 (NICU) 招募一百九十对极低出生体重早产儿。这对婴儿的人口统计和健康数据将在 NICU 收集，并在新生儿随访诊所进行更新，婴儿出院后将在新生儿随访诊所进行 3 次随访（早产校正年龄为 6、12 和 24 个月）。在这些访问期间，母婴互动将被录像 15 分钟，并将使用适合年龄的测量来收集婴儿认知/运动/语言发育结果。将在婴儿期和幼儿期（出生时、月经后 40 周以及 6、12 和 24 个月的校正年龄）同时重复测量婴儿和母亲的睾酮和皮质醇水平。首先将进行探索性数据分析，以深入了解收集的数据。广义线性模型将用于对一次性收集的独立数据进行建模，而广义估计方程和广义线性混合效应模型是对相关纵向数据进行建模的标准方法。