Electrophysiological biomarkers for spatial hearing impairments resulting from ea

ea 引起的空间听力损伤的电生理生物标志物

• 批准号: 9013467
• 负责人: Alexander T Ferber
• 金额: $ 3.16万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-03-01 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9013467
• 关键词: Acoustics; Adult; Affect; Anatomy; Animal Experiments; Animals; Auditory; Auditory Brainstem Responses; Auditory system; Basic Science; Behavior; Behavioral; Behavioral Assay; Bilateral; Binaural; Biological Markers; Brain Stem; Calibration; Cavia; Cell Nucleus; Central Auditory Processing Disorder; Child; Childhood; Chronic; Clinical; Clinical Research; Complex; Conductive hearing loss; Cues; Dependence; Detection; Development; Diagnosis; Diagnostic; Ear; Electrophysiology (science); Environment; Exposure to; Functional disorder; Hearing; Human; Impairment; Individual; Inferior Colliculus; Language; Lead; Learning; Life; Link; Location; Measures; Methods; Mission; National Institute on Deafness and Other Communication Disorders; Nature; Neurons; Otitis Media; Otitis Media with Effusion; Perception; Performance; Physiology; Process; Recovery; Research; Residual state; Resolution; Signal Transduction; Site; Sound Localization; Source; Speech; Sum; Systems Development; Technology; Testing; Time; Training; Visit; Work; behavior measurement; binaural hearing; clinical application; clinically relevant; clinically significant; design; ear infection; experience; hearing impairment; infancy; insight; language impairment; middle ear; novel; public health relevance; response; sound; superior olivary nucleus; symptom cluster; targeted treatment; tool

DESCRIPTION (provided by applicant): Conductive hearing loss (CHL)-such as is caused by middle ear infections and other ear conditions-can affect the auditory system in a profound and detrimental manner. The disruptions caused by CHL are often impairments of binaural hearing tasks that require the integration of information from both ears, such as the "filtering" of sounds in noisy and reverberant environments. Long-term speech and language impairments can result from CHL. Still today, the exact manner in which long-term CHL affects the central auditory system is not entirely known, but it is clear that the effects can be severe and long lasting. The cluster of symptoms that result are termed Central Auditory Processing Disorder (or (C)APD). Currently, diagnosis of (C)APD is difficult, requiring a battery of tests and months of time. This s problematic, since studies have shown that it is beneficial to treat (C)APD as early as possible. One potential metric that could be used to assess binaural hearing function and diagnose (C)APD is the binaural interaction component (BIC) of the auditory brainstem response (ABR). The sound-evoked binaural interaction component (BIC) is the residual auditory brainstem response (ABR) remaining after subtracting the binaurally evoked ABR from the sum of the monaurally evoked ABRs. The ¿ peak is the first negative peak in the BIC, which is related to binaural processing. Latencies of ¿ in both human and animal studies indicate it has a brainstem origin at the level of the inferior colliculus and its inputs. The inferior colliculus isa site of convergence of inputs from all brainstem nuclei, including nuclei of the superior olivary complex, which computes binaural acoustical cues to location (interaural time (ITD) and level (ILD) differences). The BIC may have important diagnostic value; for example, altered latencies and amplitudes of the ¿ peak in children and adults are correlated with and predictive of the same long-term behavioral deficits in binaural processing associated with chronic CHL. In this proposal, we investigate the effect of CHL on the BIC ¿ peak and correlate the BIC with a behavioral measure of sound localization ability, the acoustic startle response. The amplitude of and latency of the BIC ¿ peak will be assessed across a range of ITD and ILD cues to location during the course of an induced unilateral CHL, and sound localization behavior will be assessed at corresponding time points. We hypothesize that CHL alters the integration of sound localization cues in a predictable way, which will enhance our understanding of the effect of CHL on binaural hearing. Furthermore, we expect that both behavior and BIC will recover with time, with BIC predicting the level of sound localization ability. Understanding the interaction between sound localization and the BIC promises to yield a clinically useful tool for assessing binaural hearing ability and CHL in children with otitis media. This proposal is specifically designed to provide training in both basic science and clinical aspects of auditory research, furthering the mission of the NIDCD.

描述（由适用提供）：导电性听力损失（CHL） - 类似于中耳感染和其他耳朵条件造成的，以深刻而有害的方式影响听觉系统。 CHL造成的破坏通常是双耳听力任务的损害，这些任务需要从两只耳朵中整合信息，例如声音的“过滤” 在嘈杂和混响的环境中。长期的语音和语言障碍可能是CHL造成的。如今，长期CHL影响中央听觉系统的确切方式并不完全清楚，但是很明显，这种影响可能是严重且持久的。结果症状簇称为中央听觉加工障碍（或（C）APD）。目前，（C）APD的诊断很困难，需要一系列测试和数月的时间。由于研究表明，尽早治疗（c）APD是有益的，因此有问题。一种可用于评估二进制听力功能和诊断（C）APD的潜在指标是听觉脑干响应（ABR）的二元相互作用成分（BIC）。声音诱发的二进制相互作用分量（BIC）是从单龙诱发的ABR的总和中减去二进制诱发的ABR后残留的听觉脑干响应（ABR）。 «峰是BIC中的第一个负峰，与双耳处理有关。在人类和动物研究中的后来表明，它在下丘及其输入水平上具有脑干起源。来自所有脑干核的输入的colliculus isa位点，包括核复合物，该核复合物将二进制声线提示计算到位置（室内时间（ITD）和水平（ILD）差异）。 BIC可能具有重要的诊断价值；例如，儿童和成人的峰值的峰值和放大器改变与与慢性CHL相关的双耳处理中相同的长期行为缺陷相关并预测。在此提案中，我们研究了CHL对BIC峰的影响，并将BIC与声音定位能力的行为测量（声音惊吓反应）相关。在诱导的单侧CHL过程中，将评估BIC峰的放大器和延迟峰值的位置，并在相应的时间点评估声音定位行为。我们假设CHL以可预测的方式改变了声音定位线索的整合，这将增强我们对CHL对双耳听力的影响的理解。此外，我们期望行为和BIC都随着时间的流逝而恢复，而BIC可以预测声音定位能力的水平。了解声音定位与BIC之间的相互作用有望产生用于评估耳炎儿童二进制听力能力和CHL的临床有用工具。该建议专门设计旨在在听觉研究的基础科学和临床方面提供培训，从而促进NIDCD的任务。