Core C - Model Systems Core

模型系统核心项目摘要 动物模型正在彻底改变我们对IDDs的理解，这些模型提供了基本的见解 进入生物学途径，并经常显示与人类临床指标相似的表型。 疾病，提供了一个机会来推断疾病病理机制，并开发治疗方法。 模型系统核心（MSC）分为三个单元-动物行为单元，神经病理学单元 股和功能评估股。MSC的目标是提供专业知识，资源， 对参与动物和细胞模型创建和评价的中心研究者进行评估 与IDD相关，利用遗传学，脑成像，生物信息学和神经科学的优势， 在职业生涯的各个阶段为调查人员提供咨询、协助和服务。具体目标是：（1）提供 为需要评估动物行为、病理学和中枢神经系统功能的研究人员提供咨询。一 核心主任和单位领导的优先事项是确保首次使用者得到适当的指导， 服务和了解可用资源的补充; 2）描述神经功能缺损的特征， 研究人员提交的IDD啮齿动物和细胞模型。MSC被配置为提供对以下各项的接入： 一系列实验方法包括：i）小鼠和大鼠的功能表型（学习和 记忆，运动/感觉运动功能，情绪/动机的改变，社会互动，感觉 行为功能、抑郁样行为和与自闭症谱系障碍模型相关的行为; ii）组织学服务，以评估细胞水平上与缺碘症相关的变化;以及 侵入性成像（MRI，功能连接光学成像）以及体外（包括先进的 细胞模型的显微镜）和体内神经生理学评估，例如脑电图 (EEG)、多导睡眠图和体感诱发电位; 3）评估新的IDD动物模型 IDD模型中的动物行为、病理和中枢神经系统功能疗法和/或生物标志物。每个 MSC内的单元已经配置为允许快速，灵敏地测试新疗法和/或生物标志物 IDD模型; 4）整合跨单元、核心和其他现有设施的信息， 大学海安会主任将与该股领导人一道，为机构资源提供指导， 在MSC内外。与科学顾问团一起，MSC董事也将帮助 研究人员确定了用于特定基因位点、临床表型和/或筛选的最佳模型系统， 化合物来逆转被破坏的功能。WUSTL拥有最先进的专业知识和设施，为斑马鱼，C。 线虫和/或果蝇的人类疾病模型。

Model Systems Core Project Summary Animal models are revolutionizing our understanding of IDDs, and such models provide fundamental insights into biological pathways and often display phenotypes that are similar to clinical indicators of the human disease, providing an opportunity to deduce mechanisms of disease pathology, and also to develop therapies. The Model Systems Core (MSC) is organized into three units – the Animal Behavior Unit, the Neuropathology Unit, and the Functional Assessments Unit. The goal of the MSC is to provide expertise, resources, and assessment to Center investigators involved in the creation and evaluation of animal and cellular models relevant to IDD, drawing on strengths in genetics, brain imaging, bioinformatics, and neuroscience to provide advice, assistance, and services to investigators at all career stages. The specific aims are: 1) Provide consultation to investigators needing assessments in animal behavior, pathology and CNS function. A priority for the Core Directors and Unit leaders is to make certain that first-time users are guided to appropriate services and understand the complement of available resources; 2) Characterize neurological deficits in rodent and cellular models of IDD submitted by investigators. The MSC is configured to provide access to a range of experimental approaches including: i) functional phenotyping of mice and rats (learning and memory, motor/sensorimotor functions, alterations in emotionality/motivation, social interactions, sensory behavioral functions, depression-like behaviors, and behaviors related to models of Autism Spectrum Disorder; ii) histological services to evaluate IDD-related changes at the cellular level; and, iii) sophisticated, non- invasive imaging (MRI, functional connectivity optical imaging) as well as in vitro (including advanced microscopy of cellular models) and in vivo neurophysiological assessments, such as electroencephalography (EEG), polysomnography, and somatosensory evoked potentials in animal models of IDD; 3) Assess novel therapies and/or biomarkers in models of IDD in animal behavior, pathology and CNS function. Each Unit within the MSC is already configured to allow rapid, sensitive testing of novel therapies and/or biomarkers for IDD models; 4) Integrate information across units, cores and other existing facilities within the University. Together with the Unit leaders, MSC Directors will provide guidance for institutional resources both within and outside of the MSC. Together with the Scientific Advisory Panel, MSC Directors will also help investigators identify the best model system for a specific gene locus, clinical phenotype and/or screening for compounds to reverse disrupted function. WUSTL has state-of-the-art expertise and facilities for zebrafish, C. elegans, and/or Drosophila models of human disease.