Population Research and Effectiveness Core (PRE)

人口研究和有效性（PRE）核心取代并增强了先前的研究设计 和分析核心，并将有助于西奈山OAIC的目标，提供统计， 向审调处调查员提供方法和方案编制方面的专门知识，并在这些领域提供指导。这 核心小组在为审调处众多调查员提供咨询和支持方面卓有成效 面临的方法和分析问题，发生在老年人的严重疾病的研究。 对于这个应用程序，我们聚集了一批专家，其中一些人曾担任过顾问， 有些人是新的，具有广泛的知识，有关研究方法，以作为潜在的 审计和调查办公室调查员和项目顾问。将以各种方式提供资源和专门知识 并贯穿于研究过程的各个阶段--从设计到解释和展示研究结果。 除了这项研究支持外，RC-PRE还将支持一系列试点项目， 形成一个大型的，基于人口的数据集（发展项目（DP）1）的重病患者， 在其范围和包含人口统计学、医疗保健使用、慢性病 症状和功能将用于与OAIC目标相关的多个研究领域。一 第二个发展项目将改进目前分析观测数据的方法。 RC-PRE的具体目标是：1）提供先进的，尖端的方法，统计， 2）应用先进的研究和统计方法 (e.g.,倾向评分、工具变量估计、竞争风险分析），但不 （3）与区域发展合作中心和区域发展和协调中心密切合作， 初级教师接受研究方法培训，以提高他们现有的知识和专业知识; 4） 创建和管理一个大型的、基于人口的数据集，供OAIC调查人员用于以下研究： 患有严重疾病的人（DP-1），并提出分析这些数据的方法（DP-2）; 5）保持 位于西奈山的大型基于人口的数据集清单，其目标是确定结果 对严重疾病患者进行新研究的措施。通过与专家就一系列 研究中遇到的方法学、后勤学和统计学问题 老年人和研究基础设施的发展，这一核心旨在推进老年医学的严谨性， 姑息治疗研究和支持未来的老年姑息治疗研究的努力。

The Population Research and Effectiveness (PRE) Core replaces and augments the prior Research Design and Analysis Core and will contribute to the goals of the Mount Sinai OAIC by providing statistical, methodological and programming expertise, as well as mentoring in those areas, to OAIC investigators. This core has been highly productive in providing consultations and support for numerous OAIC investigators confronted with methodological and analytic issues that occur in the study of older adults with serious illness. For this application, we have assembled a cadre of experts, some who have served as past consultants and some who are new, with a broad range of knowledge regarding research methods to serve as potential consultants to OAIC investigators and projects. Resources and expertise will be provided in a variety of ways and throughout all phases of the research process - from design to interpretation and presentation of findings. In addition to this research support, the RC-PRE will support a sequence of pilot projects leading to the formation of a large, population-based dataset (Developmental Project (DP) 1) of seriously ill patients that is innovative in its scope and inclusion of information on demographics, healthcare use, chronic conditions, symptoms, and function to be used for multiple areas of research related to the objectives of the OAIC. A second developmental project will advance current methodologies for analyzing observational data. The specific aims of the RC-PRE are: 1) To provide sophisticated, cutting edge methodological, statistical, and programming support to OAIC investigators; 2) To apply advanced research and statistical methodology (e.g., propensity scores, instrumental variable estimation, competing risk analysis) used in other fields but not commonly applied to aging-related research; 3) To collaborate closely with the RCDC and RCDSC to ensure that junior faculty obtain research methods training to advance their current knowledge and expertise; 4) To create and manage a large, population-based dataset to be used by OAIC investigators for research regarding individuals with serious illness (DP-1) and advance the methods to analyze these data (DP-2); 5) To maintain an inventory of large population-based datasets housed at Mount Sinai with the goal of identifying outcome measures for new studies of patients with serious illness. Through consultations with experts on a range of topics addressing the methodological, logistical and statistical issues encountered in the study of seriously ill older adults and the development of research infrastructure, this Core aims to advance the rigor of geriatric palliative care research and support future geriatric palliative care research endeavors.