Training in Pediatric Nonmalignant Hematology and Stem Cell Biology

描述（申请人提供）：儿童血液疾病的研究为理解造血和干细胞生物学的基本机制提供了一个重要的范例。与成人血液病不同，许多儿童疾病是由控制血细胞发育或功能的内在遗传缺陷引起的。对许多儿童血液病的分子发病机制了解甚少。我们计划在儿童非恶性血液学和干细胞生物学方面与具有独特专业知识和能够培养“团队科学”的研究人员一起开发一个创新的多学科培训项目。因此，我们提出了一个整合各种学科和专业知识的培训计划，包括分子和细胞造血，替代生物模型，干细胞移植，蛋白质组学/基因组学和生物信息学的新技术。目前，斯坦福大学没有支持医学博士、医学博士/博士或博士研究员学习儿科非恶性血液学和干细胞生物学的项目。鉴于该领域的转化和基础研究人员数量的下降，在非恶性血液学和干细胞生物学方面的培训计划将是推动该领域发展的关键。在此申请中，我们每年寻求两名医学博士，医学博士/博士或博士博士后研究员，为期两年。受训者将有机会在23名教员的实验室之一开展研究。共同导师和团队科学将受到高度鼓励。实习生将根据其学术潜力、职业目标和研究成果，从大约80名内部博士后候选人和外部候选人中选拔。第二年的资助将取决于进展情况。学员将被要求参加多学科期刊俱乐部、血液学和干细胞生物学讲座、临床会议和联合研究研讨会。受训者还将学习儿童非恶性血液学和干细胞生物学（病理学290）的必修课程，由培训计划的教师导师授课。儿科血液学/肿瘤学医学博士或医学博士/博士研究员将每6个月与他们的奖学金监督委员会会面，以监督进展和生产力。学员将在国家会议上展示他们的工作，如ASH、Keystone和FASEB会议。我们希望利用斯坦福大学的优势，在儿童非恶性血液学和干细胞生物学领域开展研究合作，包括跨学科研究人员的广度和深度，培养该领域未来的领导者。

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis and stem cell biology. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understod about the molecular pathogenesis of many of the hematologic diseases in children. We plan to develop an innovative, multidisciplinary training program in pediatric nonmalignant hematology and stem cell biology with investigators who have unique expertise and can foster "team science." Therefore, we propose a training program that integrates a variety of disciplines and expertise, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, novel technologies in proteomics/genomics, and bioinformatics. Currently, there is no program at Stanford University that supports the training of MD, MD/PhD, or PhD fellows to study Pediatric Nonmalignant Hematology and Stem Cell Biology. Given the declining number of translational and basic researchers in this area, a training program in nonmalignant hematology and stem cell biology will be critical to advance the field. In this application, we seek funding for two MD, MD/PhD, or PhD postdoctoral fellows per year for two years. Trainees will have the opportunity to develop research in one of the 23-faculty member's laboratories. Co-mentors and team science will be highly encouraged. Trainees will be selected from a pool of approximately 80 internal postdoctoral fellow candidates in addition to external candidates based on their academic potential, career goals, and research achievements. The second year of funding will depend on progress. Trainees will be required to participate in multidisciplinary journal clubs, hematology and stem cell biology lectures, clinic conferences, and joint research seminars. Trainees will also take a required course on Pediatric Nonmalignant Hematology and Stem Cell Biology (Pathology 290) with lectures given by the faculty mentors in the training program. Pediatric Hematology/Oncology MD or MD/PhD fellows will meet with their Scholarship Oversight Committees every 6 months to monitor progress and productivity. Trainees will present their work at national meetings, such as ASH, Keystone, and FASEB meetings. We hope to utilize the strengths of Stanford University to develop research collaborations in pediatric nonmalignant hematology and stem cell biology, including the breadth and depth of investigators across many disciplines, to train future leaders in the field.