Training in Developmental Hematology

描述（由申请人提供）： 儿科血液疾病的研究为理解调节造血的基本机制提供了重要的范例。与成人血液疾病不同，许多儿科疾病是由控制血细胞发育或功能的内在遗传缺陷引起的。人们对大多数儿童血液疾病的分子发病机制知之甚少。在加州大学洛杉矶分校，我们拥有大量跨学科研究人员资源，他们的研究重点是与发育血液学相关的广泛主题。因此，我们提出了一个独特的培训计划，专门针对儿科血液疾病，通过整合多种学科，包括分子和细胞造血、替代生物模型、干细胞移植、止血和血栓形成、输血医学、新技术（RNA干扰、蛋白质组学、基因组学）、血液恶性肿瘤、治疗学和数学建模。鉴于儿科血液学领域的医师科学家数量不断减少，发育血液学培训计划对于推动该领域的发展至关重要。 在此申请中，我们寻求每年资助 4 名博士后研究员，为期 5 年。这些研究员将是医学博士、医学博士/博士或博士学位。学员将有机会在 22 名教员实验室之一开展研究。学员将根据学术和研究成果从大量博士后（每年约80名）中选拔。任命为期两年，第二年的任命取决于进度报告。学员将参加期刊俱乐部、儿科血液学相关讲座和研讨会。他们还将通过病理学系学习发育血液学必修课程。所有学员应每 6 个月与奖学金监督委员会会面一次，以监控进度和生产力。他们将在全国会议上展示他们的工作。许多研究人员已有合作和出版物。我们希望利用加州大学洛杉矶分校的优势，包括跨多个学科的研究人员的广度和深度，来培训儿科血液学领域未来的研究人员和领导者。 （摘要完）

DESCRIPTION (provided by applicant): Studies in pediatric blood disorders provide an important paradigm for understanding the fundamental mechanisms regulating hematopoiesis. Unlike adult hematologic disorders, many pediatric diseases result from intrinsic genetic defects that control blood cell development or function. Very little is understood about the molecular pathogenesis of most of the hematologic diseases in children. At UCLA, we have a tremendous resource of interdisciplinary investigators whose research focuses on a wide spectrum of topics related to developmental hematology. Therefore, we propose a unique training program that focuses specifically on pediatric hematologic diseases by integrating a variety of disciplines, including molecular and cellular hematopoiesis, alternative organism models, stem cell transplantation, hemostasis and thrombosis, transfusion medicine, novel technologies (RNA interference, proteomics, genomics), hematologic malignancies, therapeutics, and mathematical modeling. Given the declining number of physician-scientists in Pediatric Hematology, a training program in Developmental Hematology would be critical to advance the field. In this application, we seek funding for 4 postdoctoral fellows per year for 5 years. The fellows will be either MDs, MD/PhDs, or PhDs. Trainees will have the opportunity to develop research in one of the 22 faculty member's laboratories. Trainees will be selected from a large pool of postdoctoral fellows (approximately 80 per year) based on their academic and research achievements. Appointments will be for two years, the second year appointment being dependent on a progress report. Trainees will participate in journal clubs, lectures related to pediatric hematology, and seminars. They will also take a required course on Developmental Hematology through the Department of Pathology. All trainees will be expected to meet with a Scholarship Oversight Committee every 6 months to monitor progress and productivity. They will present their work at national meetings. Many investigators have pre-existing collaborations and publications. We hope to utilize the strengths of UCLA, including the breadth and depth of investigators across many disciplines, to train future researchers and leaders in the field of Pediatric Hematology. (End of Abstract)