Vulnerability to Drug Use & HIV: Advancing Prevention for Rural African Americans

转化和预防科学中心（CTAPS）于2009年获得资助， 通过基因环境调查，为农村非洲裔美国青年制定预防计划 (G-E)吸毒和艾滋病毒相关行为的相互作用。拟议的续设增加了 CTAPS的科学议程，以更好地解决种族差异的药物使用和艾滋病毒相关的行为，影响 农村非裔美国人新的研究表明，暴露于慢性压力会影响功能， 炎症、神经内分泌和神经认知系统的变化始于童年和青春期。的 慢性压力的负面后果影响健康相关行为，并预测慢性疾病， 衰老新出现的证据表明，这些过程也可能影响青年和年轻人的健康。 药物滥用和艾滋病毒相关行为的发展。该中心将赞助新一代的 研究（a）神经内分泌、炎症和神经认知途径， 农村非洲裔美国青年和年轻成年人的压力造成了吸毒和艾滋病毒相关的脆弱性， 行为，（B）影响潜在脆弱性的可延展风险和保护过程 （c）将调查结果转化为新的和完善的青年预防干预措施， 尤其是农村的非裔美国人。CTAPS将通过以下方式实现这些科学目标： 为三个支持核心（炎症/神经内分泌、神经认知、生物统计）提供基础设施 这将丰富来自核心项目、试点项目和试点核心项目的数据。CTAPS将促进 中心附属研究者、支持核心主管和核心项目PI之间的沟通;监督 管理中心范围内的预算和运营;为 三个支持核心和一个试点核心。CTAPS将通过跨学科工作组系统推动进展 旨在促进跨学科合作，组织中心资源的分配， 将研究成果传播给多方利益攸关方，包括研究人员、决策者、教育工作者、 组织和公众。

The Center for Translational and Prevention Science (CTAPS) was funded in 2009 to inform the development of prevention programs for rural African American youth through investigations of gene-environment (G-E) interplay on drug use and HIV-related behavior. The proposed continuation augments CTAPS' scientific agenda to better address racial disparities in drug use and HIV-related behavior that affect rural African Americans. Emerging research suggests that exposure to chronic stress affects the functioning of inflammatory, neuroendocrine, and neurocognitive systems beginning in childhood and adolescence. The negative consequences of chronic stress affect health-related behaviors and forecast chronic diseases of aging. Emerging evidence suggests that these processes also may affect youth and young adults' development of drug misuse and HIV related behavior. The Center will sponsor a new generation of research on (a) the neuroendocrine, inflammatory, and neurocognitive pathways through which exposure to stress among rural African American youth and young adults creates vulnerabilities to drug use and HIV-related behavior, (b), the malleable risk and protective processes that affect underlying vulnerability mechanisms , and (c) the translation of findings into new and refined preventive interventions for youth in general and rural African American youth in particular. The CTAPS will pursue these scientific goals via providing infrastructure for three support cores (Inflammation/Neuroendocrine, Neurocognitive, Biostatistics) that will enrich data from data from Core projects and pilot projects and a Pilot Core. CTAPS will facilitate communication among Center-affiliated investigators, support core directors, and core project Pis; oversee administration of Center-wide budgets and operations; provide infrastructure and administrative support for three support cores and a Pilot Core. CTAPS will spur progress via a transdisciplinary work group system designed to facilitate transdisciplinary collaboration and to organize the allocation of Center resources and disseminate research findings to multiple stakeholders including researchers, policy makers, educational organizations, and the public.