Physical activity restores energy homeostasis in obesity through hypothalamic neurogenesis

体力活动通过下丘脑神经发生恢复肥胖患者的能量稳态

• 批准号: nhmrc : 1005053
• 负责人: A/Pr Zane Andrews
• 金额: $ 22.27万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physical-activity-restores-hypothalamic-neurogenesis/109086
• 关键词: Physical; activity; restores; energy; homeostasis

The sensing of blood-borne signals by the brain is an important event in regulating appetite and energy expenditure. This sensing is blunted in obesity and contributes to over-eating. The aim of this research is to determine whether the sensing of these blood-borne signals can be restored in obesity by creating new cells in the key appetite controlling centres of the brain. The outcomes of this research will lead to a better understanding of how feeding behaviour can be modified to treat obesity.

大脑对血液传播信号的感知是调节食欲和能量消耗的重要事件。这种感觉在肥胖症中变得迟钝，并导致过度进食。这项研究的目的是确定这些血液传播信号的感知是否可以通过在大脑的关键食欲控制中心创造新的细胞来恢复。这项研究的结果将有助于更好地了解如何改变喂养行为来治疗肥胖。