Age- and energy-status dependent-plasticity of glucose sensing, orexigenic NPY Neurons: the glucose-ghrelin balance

葡萄糖感应、促食欲 NPY 神经元的年龄和能量状态依赖性可塑性：葡萄糖-生长素释放肽平衡

• 批准号: nhmrc : 1084600
• 负责人: A/Pr Zane Andrews
• 金额: $ 38.58万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/age-energy-status-ghrelin-balance/519017
• 关键词: Age; energy; status; dependent; plasticity

Our research aims to identify how specific brain cells detect changes in glucose levels and how ageing and diet affect their function. We identified a subset of nerve cells that detect changes in glucose and the “hunger” hormone ghrelin, their ability to do so adapting with age and nutritional status. This project will investigate the potential of these nerve cells as targets for therapeutic and diet- intervention strategies to target obesity, diabetes and promote healthy ageing

我们的研究旨在确定特定的脑细胞如何检测葡萄糖水平的变化，以及衰老和饮食如何影响它们的功能。我们确定了一个神经细胞的子集，检测葡萄糖和“饥饿”激素ghrelin的变化，他们这样做的能力随着年龄和营养状况而变化。这个项目将研究这些神经细胞作为治疗和饮食干预策略的目标的潜力，以针对肥胖，糖尿病和促进健康的老龄化。