Polymicrobial interactions in chronic periodontitis

慢性牙周炎中的多种微生物相互作用

• 批准号: nhmrc : 1008061
• 负责人: Prof Eric Reynolds
• 金额: $ 27.55万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/polymicrobial-interactions-chronic-periodontitis/109274
• 关键词: Polymicrobial; interactions; chronic; periodontitis

In this study we will determine how three pathogenic species of bacteria interact. Together these species are associated with periodontitis and they produce toxic compounds that may cause tissue damage. Using the newly emerging technologies of metabolomics and transcriptomics we will characterise these interactions. This will identify potential diagnostic biomarkers of disease and therapeutic targets.

在这项研究中，我们将确定三种致病细菌如何相互作用。这些物种一起与牙周炎有关，它们产生可能导致组织损伤的有毒化合物。利用新兴的代谢组学和转录组学技术，我们将描述这些相互作用。这将确定潜在的疾病诊断生物标志物和治疗靶点。