Characterization of a novel secretion system necessary for Porphyromonas gingivalis virulence.

牙龈卟啉单胞菌毒力所需的新型分泌系统的表征。

• 批准号: nhmrc : 509326
• 负责人: Prof Eric Reynolds
• 金额: $ 39.77万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterization-novel-secretion-gingivalis-virulence/81915
• 关键词: Characterization; novel; secretion; system; necessary

In this study we will characterize a novel bacterial secretion system that we have discovered. This sytem mediates the secretion of proteins from the bacterial cell and their attachment to the cell surface. This system is essential for the virulence of Porphyromonas gingivalis, a bacterium associated with chronic periodontitis. The chacterization of this system may offer opportunities for the development of new treatments to target this disease.

在这项研究中，我们将描述一种新的细菌分泌系统，我们已经发现。该系统介导蛋白质从细菌细胞分泌并附着到细胞表面。该系统对于牙龈卟啉单胞菌（一种与慢性牙周炎相关的细菌）的毒力是必不可少的。该系统的特征化可能为开发针对该疾病的新治疗方法提供机会。