Precision molecular diagnostics of single cells by imaging flow cytometry

通过成像流式细胞术对单细胞进行精确分子诊断

• 批准号: nhmrc : 2004957
• 金额: $ 87.51万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/precision-molecular-diagnostics-flow-cytometry/1780422
• 关键词: Precision; molecular; diagnostics; single; cells

We have invented a highly sensitive, new method to count and evaluate chromosomes inside cancer cells. With this world-first method we can detect abnormal chromosomes when fewer than 1 cell in 1,000 is affected. We will refine the method for assessment of blood cancers and chromosome disorders such as trisomy 21 (Down Syndrome), and commence pre-clinical testing. This is a critical step towards translating this methodology into a validated test to significantly benefit human health.

我们发明了一种高灵敏度的新方法来计数和评估癌细胞内的染色体。通过这种世界首创的方法，我们可以在1,000个细胞中少于1个细胞受到影响时检测到异常染色体。我们将改进血癌和染色体疾病（如21三体综合征）的评估方法，并开始临床前测试。这是将这种方法转化为有效测试以显着造福人类健康的关键一步。