Predicting treatment response to onabotulinumtoxin-a in MS-related tremor: a combined clinical, electrophysiological and neuroimaging approach.

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Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.