Predicting treatment response to onabotulinumtoxin-a in MS-related tremor: a combined clinical, electrophysiological and neuroimaging approach.

预测多发性硬化症相关震颤中肉毒杆菌毒素 a 的治疗反应：临床、电生理学和神经影像学相结合的方法。

• 批准号: nhmrc : GNT1085461
• 负责人: A/Pr Anneke van der Walt
• 金额: $ 52.49万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/predicting-treatment-response-neuroimaging-approach/1345628
• 关键词: Predicting; treatment; response; onabotulinumtoxin; MS

Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.

多发性硬化症（MS）患者的上肢会出现颤抖（震颤）。我们以前已经证明，肉毒杆菌毒素（Botox）注射可以帮助减少震颤。这项研究的目的是研究肉毒杆菌素在更大规模的MS患者中的作用，并将包括详细的MRI扫描和电震颤监测测试，以确定导致震颤的大脑潜在变化。研究结果将有助于肉毒杆菌毒素作为一种震颤治疗MS患者。