Predicting treatment response to onabotulinumtoxin-a in MS-related tremor: a combined clinical, electrophysiological and neuroimaging approach.

上肢震颤（震颤）发生在许多多发性硬化症（MS）患者身上。我们之前已经证明肉毒杆菌毒素（Botox）注射可以帮助减少震颤。这项研究的目的是研究肉毒杆菌毒素在更大的多发性硬化患者群体中的作用，并将包括详细的核磁共振扫描和电震颤监测测试，以确定导致震颤的大脑潜在变化。研究结果将有助于使肉毒杆菌毒素成为多发性硬化症患者的震颤治疗药物。

Shaking (tremor) of the upper limbs occur in many people with multiple sclerosis (MS). We have previously shown that botulinum toxin (Botox) injections could help reduce tremor. This study aims to study the effect of Botox in a larger group of people with MS and will include detailed MRI scans and electrical tremor monitoring tests to define the underlying changes in the brain that causes tremor. The results will help make Botox available as a tremor treatment for people with MS.