Presynaptic control of general anaesthesia

全身麻醉的突触前控制

• 批准号: nhmrc : GNT1164879
• 金额: $ 78.66万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/presynaptic-control-general-anaesthesia/1379373
• 关键词: Presynaptic; control; general; anaesthesia

We have recently discovered a new mechanism for general anaesthesia. Sedatives such as propofol first put you to sleep, but then do something completely different: they impair communication between neurons across the brain. We need to better understand exactly how this happens, for the different drugs used during surgery. This understanding will allow us to design more targeted approaches for general anaesthesia, with better temporal control during surgery as well as minimal side effects.

我们最近发现了一种新的全身麻醉机制。异丙酚等镇静剂首先会让你入睡，但随后会产生完全不同的作用：它们会损害大脑神经元之间的通讯。我们需要更好地了解手术期间使用的不同药物是如何发生这种情况的。这种理解将使我们能够设计更有针对性的全身麻醉方法，在手术过程中实现更好的时间控制以及最小的副作用。