Prevention of multi-drug resistant tuberculosis in a high prevalence setting: ‘Connecting the DOTS’ in Vietnam

在高患病率环境中预防耐多药结核病：越南的“连接 DOTS”

• 批准号: nhmrc : GNT1081443
• 负责人: A/Pr Gregory Fox
• 金额: $ 323.45万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/prevention-multi-drug-dots-vietnam/1345404
• 关键词: Prevention; multi; drug; resistant; tuberculosis

The close contacts of people with multi-drug resistant tuberculosis (MDR-TB) have a high risk of developing the disease. The V-QUIN MDR-TB Trial will evaluate the effectiveness of an oral antibiotic (levofloxacin) in preventing drug resistant TB among infected household contacts of TB patients. Household contacts from 10 Provinces in Vietnam will be randomly allocated to receive six-months of either levofloxacin or a placebo, and then followed for two years to see if they develop tuberculosis.

与耐多药结核病（MDR-TB）患者的密切接触者患该病的风险很高。V-QUIN耐多药结核病试验将评估口服抗生素（左氧氟沙星）在结核病患者的受感染家庭接触者中预防耐药结核病的有效性。来自越南10个省的家庭接触者将被随机分配接受6个月的左氧氟沙星或安慰剂，然后随访两年，看看他们是否患上结核病。