Protein recognition of small RNAs in innate immunity

先天免疫中小RNA的蛋白质识别

• 批准号: nhmrc : 1006590
• 负责人: A/Pr Jacqueline Wilce
• 金额: $ 44.44万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/protein-recognition-small-innate-immunity/109197
• 关键词: Protein; recognition; small; RNAs; innate

Protein-RNA interactions are critical in the immune response to virus infections. Small interfering RNAs (siRNAs) are important tools in the discovery of gene function and have great potential for therapy against viral infections and cancer, but can also activate the innate immune system. By characterising the determinants of small RNA sensing by the sensors of the immune system and the protein-RNA interactions involved, we will gain new insights into the design of siRNAs for use in the clinic.

蛋白质-RNA相互作用在对病毒感染的免疫应答中至关重要。小干扰RNA（siRNA）是发现基因功能的重要工具，在治疗病毒感染和癌症方面具有巨大潜力，但也可以激活先天免疫系统。通过表征免疫系统传感器和所涉及的蛋白质-RNA相互作用的小RNA传感的决定因素，我们将获得新的见解siRNAs的设计用于临床。