Characterisation of the growth receptor bound 7 (Grb7) protein and protein and RNA partners involved in the regulation of stress granule formation and cell migration.

生长受体结合 7 (Grb7) 蛋白以及参与应激颗粒形成和细胞迁移调节的蛋白和 RNA 伴侣的表征。

• 批准号: nhmrc : 1004332
• 负责人: A/Pr Jacqueline Wilce
• 金额: $ 42.94万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-growth-receptor-cell-migration/109023
• 关键词: Characterisation; growth; receptor; bound; Grb7

This proposal is to investigate the Grb7 protein that occurs at very high levels in some types of cancer cells, including breast cancer cells. It is thought that Grb7 contributes to the progression of cancer by directly affecting the regulation of other genes. We will investigate the way in which this protein interacts with other proteins and RNA that could underlie the cancer growth and spread. A better understanding of the Grb7 protein will help to establish its potential as a novel drug target.

该提案旨在研究Grb7蛋白，该蛋白在某些类型的癌细胞（包括乳腺癌细胞）中以非常高的水平存在。据认为，Grb7通过直接影响其他基因的调节而促进癌症的进展。我们将研究这种蛋白质与其他蛋白质和RNA相互作用的方式，这些蛋白质和RNA可能是癌症生长和扩散的基础。更好地了解Grb7蛋白将有助于建立其作为新药物靶点的潜力。