Characterisation of TIA proteins in RNA recognition and stress granule formation

TIA 蛋白在 RNA 识别和应激颗粒形成中的表征

• 批准号: nhmrc : 1105801
• 负责人: A/Pr Jacqueline Wilce
• 金额: $ 38.87万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/characterisation-tia-proteins-granule-formation/662858
• 关键词: Characterisation; TIA; proteins; RNA; recognition

Cells in our body need to be able to respond to stresses such as heat, hypoxia, chemical stress or infection. In this project we investigate the specialized TIA proteins that have the job of protecting RNA in stressed cells. We will investigate the way TIA proteins recognize particular mRNA and form temporary protective clusters. By better understanding this process we will gain insight into the way in which cells are susceptible to damage in diseases including neurodegenerative disease.

我们体内的细胞需要能够对热、缺氧、化学应激或感染等压力做出反应。在这个项目中，我们研究了在应激细胞中具有保护RNA功能的特化TIA蛋白。我们将研究TIA蛋白识别特定mRNA并形成临时保护簇的方式。通过更好地了解这一过程，我们将深入了解细胞在包括神经退行性疾病在内的疾病中容易受到损害的方式。