Design and delivery of peptide-based anti-cancer Grb7 inhibitors

Grb7蛋白在许多类型的癌细胞中过量产生，并在癌细胞的生长和扩散中发挥作用。目前的建议建立在发现一种具有抗癌活性的肽基Grb7抑制剂的基础上。这一建议是制备更有效的抑制剂分子，可以有效地到达目标癌细胞。这些分子将用于Grb7的研究和开发新的基于Grb7的抗癌药物治疗。

The Grb7 protein is overproduced in many types of cancer cells and plays a role in cancer cell growth and spread. The current proposal builds upon the discovery of a peptide-based Grb7 inhibitor that has anti-cancer activity. This proposal is to prepare more potent inhibitor molecules that can efficiently reach the target cancer cells. Such molecules will be used for the study of Grb7 and for the development of a new Grb7-based anti-cancer drug therapy.