Altered HCN channel expression and function in acquired epilepsy

获得性癫痫中 HCN 通道表达和功能的改变

• 批准号: nhmrc : 454655
• 负责人: A/Pr Christopher Reid
• 金额: $ 18.66万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/altered-hcn-channel-acquired-epilepsy/82871
• 关键词: Altered; HCN; channel; expression; function

About 100 000 people currently suffer from epilepsy in Australia and of these about one third are poorly controlled with current anti-epileptic drugs. It is therefore important to continue to develop novel modes of treatment for this debilitating disease. This projects investigates an ion channel, known as the HCN channel, that is thought to be involved in making a brain epileptic. We explore how changes in this channel can make a brain more excitable. Also, our group is the first in the world to discover a mutation in this channel that is linked to epilepsy. We will also investigate how this mutation changes the channel properties to make a brain more likely to be epileptic. The HCN channel is an important target for developing anti-epileptic drugs. Understanding how changes in HCN channels make nerve cells and therefore nerve cell networks more excitable will help us develop better strategies for designing anti-epileptic drugs.

目前，澳大利亚约有10万人患有癫痫，其中约三分之一的人使用目前的抗癫痫药物控制不佳。因此，重要的是要继续开发新的模式治疗这种衰弱性疾病。该项目研究了一种被称为HCN通道的离子通道，该通道被认为与大脑癫痫有关。我们探索这个通道的变化如何使大脑更加兴奋。此外，我们的团队是世界上第一个发现与癫痫有关的这个通道突变的团队。我们还将研究这种突变如何改变通道特性，使大脑更容易癫痫。HCN通道是开发抗癫痫药物的重要靶点。了解HCN通道的变化如何使神经细胞和神经细胞网络更加兴奋，将有助于我们开发更好的抗癫痫药物设计策略。