Changing the course of epileptogenesis

改变癫痫发生的过程

• 批准号: nhmrc : 628520
• 负责人: A/Pr Christopher Reid
• 金额: $ 35.64万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/changing-course-epileptogenesis/76140
• 关键词: Changing; course; epileptogenesis

Epilepsy is a serious condition having a massive impact on individuals and the community at large. Our understanding of the genetic causes of epilepsy is growing rapidly. We have created new animal models based on human mutations. We have shown that mutations can change the wiring of the brain during development so that the adult brain is more likely to become epileptic. Projects in this grant test if we can stop this developmental impact- allowing us to treat epilepsy before seizures occur.

癫痫是一种严重的疾病，对个人和整个社区产生巨大影响。我们对癫痫遗传原因的了解正在迅速增长。我们根据人类突变创建了新的动物模型。我们已经证明，突变可以改变发育过程中大脑的线路，从而使成年大脑更有可能患癫痫。这项资助的项目测试我们是否能够阻止这种发育影响——使我们能够在癫痫发作之前治疗癫痫。