Changing the course of epileptogenesis

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Epilepsy is a serious condition having a massive impact on individuals and the community at large. Our understanding of the genetic causes of epilepsy is growing rapidly. We have created new animal models based on human mutations. We have shown that mutations can change the wiring of the brain during development so that the adult brain is more likely to become epileptic. Projects in this grant test if we can stop this developmental impact- allowing us to treat epilepsy before seizures occur.