Mechanisms underlying short- and long-term plasticity at the mossy fibre -> CA3 synapse in the hippocampus

苔藓纤维短期和长期可塑性的机制 -

• 批准号: nhmrc : 236801
• 负责人: A/Pr Christopher Reid
• 金额: $ 18.19万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-underlying-short-synapse-hippocampus/97943
• 关键词: Mechanisms; underlying; short; long; term

Synapses, the contacts between brain cells, are extremely plastic. They can become stronger and weaker depending on the activity they experience. The hippocampus, a structure in the brain, is known to be critical to the formation of conscious memories. The plastic nature of the synapse in this structure is thought to underlie learning and memory. Understanding the mechanisms that are responsible for the changes in synaptic strength in the hippocampus are therefore important to our understanding of learning and memory. This proposal describes a series of experiments that are designed to determine the mechanisms of plastic changes . We hope, that by understanding these mechanisms, we can start to understand how we learn and remember.

突触，脑细胞之间的联系，是非常可塑的。他们可以变得更强或更弱，这取决于他们所经历的活动。海马体是大脑中的一个结构，对有意识记忆的形成至关重要。这种结构中突触的可塑性被认为是学习和记忆的基础。因此，了解海马体中突触强度变化的机制对我们理解学习和记忆非常重要。该提案描述了一系列旨在确定塑性变化机制的实验。我们希望，通过了解这些机制，我们可以开始了解我们如何学习和记忆。