Do changes in HCN channels function cause epilepsy?

HCN通道功能的改变会导致癫痫吗？

• 批准号: nhmrc : 1009142
• 负责人: A/Pr Christopher Reid
• 金额: $ 25.75万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/changes-hcn-channels-cause-epilepsy/109374
• 关键词: Do; changes; HCN; channels; function

About 100 000 people suffer from epilepsy in Australia with about one third poorly controlled with current anti-epileptic drugs. It is important to continue to develop novel modes of treatment for this debilitating disease. This project investigates an ion channel, known as HCN that is thought to be involved in making a brain epileptic. Understanding how changes in HCN channels make nerve cells and nerve networks more excitable will help us develop better strategies for designing drugs.

在澳大利亚，大约有10万人患有癫痫，其中约三分之一的人在目前的抗癫痫药物下控制不佳。继续开发针对这种使人衰弱的疾病的新型治疗模式非常重要。该项目研究了一种被称为HCN的离子通道，它被认为与大脑癫痫有关。了解HCN通道的变化如何使神经细胞和神经网络更加兴奋，将有助于我们开发更好的药物设计策略。