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An investigation into the molecular basis of MAIT cell recognition of vitamin B based metabolites

An investigation into the molecular basis of MAIT cell recognition of vitamin B based metabolites
MAIT 细胞识别维生素 B 代谢物的分子基础研究
批准号:
nhmrc : 1063587
负责人:
Dr Alexandra Corbett
金额:
$58.93万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31

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中文摘要
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英文摘要
Mucosal associated invariant T cells (MAIT cells) are an abundant T-cell population in humans, that is found mostly in the gastrointestinal mucosa. We have recently shown that MAIT cells can be activated by metabolites of vitamin B. This proposal will investigate how the MAIT cells "see" vitamin B metabolites. This research will pave the way for novel therapeutics that can modulate MAIT cell activity.
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