Understanding the Role of MAIT cells in health and Disease

了解 MAIT 细胞在健康和疾病中的作用

• 批准号: nhmrc : 1062889
• 负责人: Dr Alexandra Corbett
• 金额: $ 36.51万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-mait-health-disease/455027
• 关键词: Understanding; Role; MAIT; cells; health

A specialised set of T lymphocytes called Mucosal Associated Invariant T (MAIT) cells protect us from bacteria and yeast at mucosal sites where the body's immune defences are most easily breached, e.g. gut, oral cavity, airways & reproductive tract. This study investigates the role of MAIT cells in health and in diseases like inflammatory bowel disease, peptic ulceration, periodontitis and tuberculosis. Controlling MAIT cells could help in treating these conditions.

一组专门的T淋巴细胞称为粘液相关的不变T（MAIT）细胞，保护我们免受细菌和酵母菌在粘膜部位，身体的免疫防御最容易被破坏，例如肠道，口腔，气道和生殖道。这项研究调查了MAIT细胞在健康和炎症性肠病、消化性溃疡、牙周炎和结核病等疾病中的作用。控制MAIT细胞可以帮助治疗这些疾病。