A structural, chemical and functional investigation into MAIT cell receptor recognition

MAIT 细胞受体识别的结构、化学和功能研究

• 批准号: nhmrc : 1125493
• 负责人: Dr Alexandra Corbett
• 金额: $ 81.74万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-chemical-functional-receptor-recognition/947608
• 关键词: structural; chemical; functional; investigation; into

This project is focused on a type of T-cell, termed a MAIT cell, which is found abundantly in the lining of the gut. We are investigating how this MAIT cell is activated by riboflavin and folic acid metabolites. We are also examining how commonly prescribed drugs impact MAIT cells and how such activation may be linked to diseases, including inflammatory bowel disease.

这个项目的重点是一种被称为MAIT细胞的T细胞，这种细胞在肠道的衬里中大量存在。我们正在研究核黄素和叶酸代谢产物是如何激活这种MAIT细胞的。我们还在研究常用药物如何影响MAIT细胞，以及这种激活可能与包括炎症性肠病在内的疾病有关。