Antibiotic peptides that inhibit ATP synthase

抑制 ATP 合酶的抗生素肽

• 批准号: nhmrc : 1146403
• 负责人: Dr Alastair Stewart
• 金额: $ 31.33万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/antibiotic-peptides-inhibit-atp-synthase/1320652
• 关键词: Antibiotic; peptides; inhibit; ATP; synthase

Antibiotic resistant bacteria cause life-threatening diseases and represent a major public health problem. Globally, drug-resistant infections currently cause over 500,000 deaths annually and this figure is projected to exceed 10 million by 2050. Venom peptides are a new avenue of antibiotic discovery. This proposal aims to define how these peptides interact with the cellular power generator, ATP synthase, to provide a basis for exploiting their potential to treat bacterial infections.

抗生素耐药性细菌导致危及生命的疾病，并代表了一个主要的公共卫生问题。在全球范围内，抗药性感染目前每年造成50多万人死亡，预计到2050年这一数字将超过1 000万人。毒液肽是发现抗生素的新途径。该提案旨在确定这些肽如何与细胞发电机ATP合酶相互作用，为开发其治疗细菌感染的潜力提供基础。