The structural basis for promiscuity of drug binding to hERG K+ channels

药物与 hERG K 通道结合混杂的结构基础

• 批准号: nhmrc : GNT1141974
• 负责人: Dr Alastair Stewart
• 金额: $ 71.3万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/structural-basis-promiscuity-k-channels/1348422
• 关键词: structural; basis; promiscuity; drug; binding

Special proteins called ion channels control the electrical activity of the heart. Drugs that block ion channels can have the unwanted side-effect of altering the rhythm of the heart beat and causing sudden cardiac death. Extensive efforts are made to screen for this problem during drug development but it is still an inexact science. Here we will use high resolution imaging technologies to get a better understanding of how drugs bind to ion channel proteins.

一种叫做离子通道的特殊蛋白质控制着心脏的电活动。阻断离子通道的药物可能会产生意想不到的副作用，即改变心脏跳动的节奏，导致心源性猝死。在药物开发过程中进行了广泛的努力来筛选这个问题，但它仍然是一门不精确的科学。在这里，我们将使用高分辨率成像技术来更好地了解药物如何与离子通道蛋白结合。