ATP synthase: Regulation, antibiotics and mitochondrial disease

ATP 合酶：调节、抗生素和线粒体疾病

• 批准号: nhmrc : GNT1159347
• 负责人: Dr Alastair Stewart
• 金额: $ 43.7万
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/atp-synthase-regulation-mitochondrial-disease/1349289
• 关键词: ATP; synthase; Regulation; antibiotics; mitochondrial

ATP synthase is an essential large biological enzyme that generates large amounts of cellular energy. Mutations in ATP synthase are important in many medical mitochondrial pathologies, including cardiomyopathies, heart failure and dementia. This proposal aims to image this essential enzyme at the atomic scale and exploit this knowledge to develop novel antibiotics and to understand how mutations in its components generate mitochondrial diseases.

三磷酸腺苷合成酶是一种重要的大型生物酶，能产生大量的细胞能量。ATP合酶的突变在包括心肌病、心力衰竭和痴呆症在内的许多医学线粒体病理中都是重要的。这项提议旨在在原子尺度上对这种关键酶进行成像，并利用这一知识开发新的抗生素，并了解其组成部分的突变是如何导致线粒体疾病的。