The associations between cognitive decline and genetic polymorphisms, hormones and cardiovascular risk factors in women.

女性认知能力下降与遗传多态性、激素和心血管危险因素之间的关联。

• 批准号: nhmrc : 547600
• 负责人: Prof Cassandra Szoeke
• 金额: $ 23.88万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/associations-cognitive-decline-factors-women/115940
• 关键词: associations; between; cognitive; decline; genetic

Dementia, a major cause of morbidity and mortality in ageing women, has been linked to hormonal changes and genes. If factors associated with impaired cognition and early Alzheimer's disease could be identified then early interventions could be offered to those at risk. In this study we determine the genetic, medical and lifestyle factors which may be associated with cognitive decline and early Alzheimer's disease in women from pre-menopause into their post-menopausal years.

痴呆症是老年妇女发病和死亡的主要原因，与荷尔蒙变化和基因有关。如果与认知受损和早期阿尔茨海默病相关的因素能够被确定，那么就可以为那些有风险的人提供早期干预措施。在这项研究中，我们确定了遗传、医学和生活方式因素，这些因素可能与女性从绝经前到绝经后的认知能力下降和早期阿尔茨海默病有关。