The cellular and molecular basis to the paradox of positive versus negative T cell selection

阳性与阴性 T 细胞选择悖论的细胞和分子基础

• 批准号: nhmrc : 124492
• 负责人: Prof Richard Boyd
• 金额: $ 18.54万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cellular-molecular-basis-cell-selection/95183
• 关键词: cellular; molecular; basis; paradox; positive

The protection against disease requires the generation of white blood cells called T lymphocytes that are produced in the thymus. Each T cell has a specific surface receptor, generated by random gene switching, that can react against foreign pathogens. Since there is a very high conservation of molecules used in all organisms, some of these receptors could by chance also react against normal cells in the host. Eliminating all such self-reactive cells would mean, however, the repertoire remaining for eliminating infection would be too low and immunodeficiency develops. This project investigates the mechanisms controlling the balance between defence infection and the need to prevent immune-based self destruction termed autoimmunity.

预防疾病需要胸腺中产生称为 T 淋巴细胞的白细胞。每个 T 细胞都有一个由随机基因转换产生的特定表面受体，可以对外来病原体做出反应。由于所有生物体中使用的分子都具有非常高的保守性，因此其中一些受体也可能偶然对宿主中的正常细胞发生反应。然而，消除所有此类自身反应细胞将意味着消除感染的剩余能力太低，并且会出现免疫缺陷。该项目研究控制防御感染与防止基于免疫的自我毁灭（称为自身免疫）的需要之间的平衡机制。