The generation, fate and functional potential of recent thymic emigrants

近期胸腺移民的产生、命运和功能潜力

• 批准号: nhmrc : 124563
• 负责人: Prof Richard Boyd
• 金额: $ 21.26万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generation-fate-functional-thymic-emigrants/101503
• 关键词: generation; fate; functional; potential; recent

A particular kind of white blood cell, called a T lymphocyte, is responsible for controlling our immune responses to foreign invaders. These cells develop in the thymus, where they learn to distinguish between foreign invaders and self tissue, before emigrating to other organs. The regulation of this process is important to maintain a pool of T lymphocytes in the body. It is important that T lymphocytes do not respond against self tissue, as this can lead to a Oself destructO disease called autoimmunity. Since these developing T lymphocytes will not see all kinds of self tissue while in the thymus, we propose that their education to prevent self-tissue reactivity may continue for some time after they leave the thymus.

一种特殊的白细胞，称为 T 淋巴细胞，负责控制我们对外来入侵者的免疫反应。这些细胞在胸腺中发育，在迁移到其他器官之前，它们学会区分外来入侵者和自身组织。这一过程的调节对于维持体内 T 淋巴细胞池非常重要。重要的是，T 淋巴细胞不会对自身组织产生反应，因为这可能导致称为自身免疫的自身破坏疾病。由于这些发育中的 T 淋巴细胞在胸腺中不会看到各种自身组织，因此我们建议，在它们离开胸腺后，可能会继续对它们进行防止自身组织反应的教育一段时间。