The coronary vascular bed, shear stress, endothelial signalling and myocyte electrophysiology

冠状血管床、剪切应力、内皮信号传导和肌细胞电生理学

• 批准号: nhmrc : 106930
• 负责人: Prof David Kilpatrick
• 金额: $ 8.92万
• 依托单位: Antarctic Climate and Ecosystems CRC, University of Tasmania
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/coronary-vascular-bed-myocyte-electrophysiology/81217
• 关键词: coronary; vascular; bed; shear; stress

Physiologic control muscle performance includes a little understood signal from the walls of blood vessels stimulated by pressure and flow which effect muscle function. How this signal operates is controversial. We have developed a model which enables the evaluation of such signalling where changes in flow in the circumflex coronary artery induce easily measured local changes in electrophysiology which are confined to the territory of the circumflex coronary artery and which can be compared with control values from the left anterior descending coronary artery territory. We propose to use this stable model to evaluate the origin, the transmission agent and the mechanism by which it alters the action potential duration.

生理控制肌肉性能包括来自影响肌肉功能的压力和流量刺激的血管壁的鲜为人知的信号。该信号的运作方式存在争议。我们开发了一种模型，可以评估此​​类信号传导，其中回旋冠状动脉中的血流变化引起容易测量的电生理学局部变化，这些变化仅限于回旋冠状动脉区域，并且可以与左冠状动脉前降支区域的控制值进行比较。我们建议使用这个稳定的模型来评估起源、传输介质及其改变动作电位持续时间的机制。