The differential innervation of fat - potential to target visceral adiposity

脂肪的差异神经支配——针对内脏肥胖的潜力

• 批准号: nhmrc : 1010318
• 负责人: Prof Brian Oldfield
• 金额: $ 32.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/differential-innervation-fat-visceral-adiposity/109480
• 关键词: differential; innervation; fat; potential; target

Levels of abdominal fat are closely correlated with metabolic syndrome. We propose experiments to identify unique characteristics (neurotransmitters or receptors) of neurons deep in the brain that project specifically to this type of fat or other less harmful subcutaneous fat. We can then test the functional significance of these unique elements in animal experimets involving gene knockdown or pharmacological approaches to modify their function and test the effect on fat distribution

腹部脂肪水平与代谢综合征密切相关。我们提出实验来确定大脑深处神经元的独特特征（神经递质或受体），这些神经元专门投射到这种类型的脂肪或其他危害较小的皮下脂肪。然后，我们可以在动物实验中测试这些独特元素的功能意义，包括基因敲除或药理学方法来改变它们的功能，并测试对脂肪分布的影响。