Brain glucose-sensing: age- and energy-status-dependent plasticity of function-specific Pro-opiomelanocortin (POMC) glucose-sensing neurons in the arcuate nucleus of the hypothalamus

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Obesity and ageing predispose individuals to diabetes, the health and socio-economic implications of which posing significant challenges for Australia in the foreseeable future. Research outlined here aims to identify novel mechanisms enabling brain cells to detect changes in glucose and how ageing and diet affect the function of these nerves. We believe this research could provide novel therapeutic and early diet-based intervention strategies for diabetes and obesity.