Brain glucose-sensing: age- and energy-status-dependent plasticity of function-specific Pro-opiomelanocortin (POMC) glucose-sensing neurons in the arcuate nucleus of the hypothalamus

大脑葡萄糖感应：下丘脑弓状核中功能特异性阿黑皮质素原 (POMC) 葡萄糖感应神经元的年龄和能量状态依赖性可塑性

• 批准号: nhmrc : 1063955
• 负责人: Prof Brian Oldfield
• 金额: $ 33.01万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/brain-glucose-sensing-nucleus-hypothalamus/455092
• 关键词: Brain; glucose; sensing; age; energy

Obesity and ageing predispose individuals to diabetes, the health and socio-economic implications of which posing significant challenges for Australia in the foreseeable future. Research outlined here aims to identify novel mechanisms enabling brain cells to detect changes in glucose and how ageing and diet affect the function of these nerves. We believe this research could provide novel therapeutic and early diet-based intervention strategies for diabetes and obesity.

肥胖和老龄化使个人易患糖尿病，其健康和社会经济影响在可预见的将来对澳大利亚构成重大挑战。这里概述的研究旨在确定使脑细胞检测葡萄糖变化的新机制，以及衰老和饮食如何影响这些神经的功能。我们相信这项研究可以为糖尿病和肥胖提供新的治疗和早期饮食干预策略。