The impact of circadian disturbances on sleep quality, cognition and psychiatric symptoms in neurodegenerative disease

人们越来越意识到，神经退行性疾病与睡眠障碍有关。我们小组已经认识到，这些患者的睡眠障碍模式也与记忆和情绪问题有关。这项拟议的研究将是第一次探索昼夜节律系统的中断是否代表了这些并存疾病特征背后的共同机制。对这种病理的了解有望导致新疗法的发展。

There is an increasing awareness that neurodegenerative diseases are associated with disturbances in sleep. Our group have recognised that patterns of sleep disturbance in these patients are also related to problems with memory and mood. The proposed study will be the first of its kind to explore whether disruptions in the circadian system represent a common mechanism underlying these comorbid disease features. Understanding this pathology will hopefully lead to the development of new therapies.