The phenotype of protective cytotoxic T cell responses during viral infections

病毒感染期间保护性细胞毒性 T 细胞反应的表型

• 批准号: nhmrc : 1121643
• 负责人: A/Pr Fabio Luciani
• 金额: $ 57.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/phenotype-protective-cytotoxic-viral-infections/946777
• 关键词: phenotype; protective; cytotoxic; cell; responses

T cell responses are important to establish protection against pathogens and some cancer via generation of memory cells that can be maintained long term and defeat promptly re-infections. This proposal aim at determining important factors that drive the success of immunological memory by employing single cell technologies and unique longitudinal samples from subjects infected with hepatitis C virus. The finding of this study will inform current vaccine research and immunotherapies.

T细胞反应对于通过产生记忆细胞来建立对病原体和一些癌症的保护非常重要，这些记忆细胞可以长期保持并迅速战胜再次感染。这项建议旨在通过使用单细胞技术和来自丙型肝炎病毒感染者的独特的纵向样本来确定推动免疫记忆成功的重要因素。这项研究的发现将为当前的疫苗研究和免疫疗法提供信息。