Systems immunology of antigen specific T cells: from single-cell to immune protection

抗原特异性T细胞的系统免疫学：从单细胞到免疫保护

• 批准号: nhmrc : 1128416
• 负责人: A/Pr Fabio Luciani
• 金额: $ 32.12万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/systems-immunology-antigen-immune-protection/948211
• 关键词: Systems; immunology; antigen; specific; cells

T cells are key for establishment of immune protection and object of ongoing research in vaccines and more recently immunotherapy against infections and some cancers. Their dynamics are complex and many mechanisms remain unknown that could be exploited for modern therapies. Here, in a systems approach I will combined single cell technologies, immunology and computational biology to identify the factors that determine the establishment of long term memory cells utilising a unique set of samples.

T细胞是建立免疫保护的关键，也是疫苗和最近针对感染和某些癌症的免疫治疗正在进行的研究的对象。它们的动力学是复杂的，许多机制仍不清楚，可以用于现代疗法。在这里，我将用系统的方法结合单细胞技术、免疫学和计算生物学，利用一组独特的样本来确定决定长期记忆细胞建立的因素。