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Virological determinants of drug resistance in real-world patients with chronic HCV infection

Virological determinants of drug resistance in real-world patients with chronic HCV infection
现实世界慢性 HCV 感染患者耐药性的病毒学决定因素
批准号:
nhmrc : 1066537
负责人:
A/Pr Fabio Luciani
金额:
$36.72万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2014
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2014-01-01 至 2016-12-31

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中文摘要
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英文摘要
New treatments for hepatitis C virus (HCV) infection are emerging. These drugs directly target key events in the viral life cycle. While these drugs are effective, the ability of HCV to mutate means that drug resistance can arise, leading to treatment failure. This is most likely in patients who do not respond to interferon-based therapy. This proposal will use new, highly sensitive sequencing approaches to identify the viral mutations and evolutionary pathways that lead to drug resistance.
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