Determining the unique processes that control memory B cell-mediated secondary antibody responses

确定控制记忆 B 细胞介导的二抗反应的独特过程

• 批准号: nhmrc : 1124681
• 负责人: A/Pr Fabio Luciani
• 金额: $ 58.34万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determining-unique-processes-antibody-responses/947413
• 关键词: Determining; unique; processes; control; memory

Vaccines educate the immune system by training memory cells to make neutralizing antibodies when it re-encounters the pathogen. However, where and how these memory cells are activated in the secondary antibody response in immune animals remain unknown. Here we use cutting edge technologies to fate map and gene profile memory cells and determine the molecular switches that control the secondary antibody response. This will be complemented by human vaccine studies.

疫苗通过训练记忆细胞来训练免疫系统，使其在再次遇到病原体时产生中和抗体。然而，在免疫动物的二抗反应中，这些记忆细胞在哪里以及如何被激活仍然未知。在这里，我们使用尖端的技术来命运图和基因谱记忆细胞，并确定控制二抗反应的分子开关。这将得到人体疫苗研究的补充。