Assessment of the effects of pathogenic germline TP53 mutations; International Sarcoma Kindred Study participants’ views of feedback of genetic research results and the acceptability of taking part in a pilot screening programme

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The International Sarcoma Kindred Study (ISKS) aims to identify individuals who harbour germline TP53 mutations. TP53 mutations are characterised by the development of multiple cancers including sarcoma. This project will assess ISKS participants’ views of the feedback of genetic research information and will develop sensitive feedback practices. The acceptability and psychological impact of taking part in a pilot screening protocol designed for cancer-prone populations will also be assessed.