Astroglial remodelling of the interhemispheric midline is regulated by deleted in colorectal cancer (DCC) signalling and is required for corpus callosum formation

大脑两个半球之间的信息整合是通过一大束连接的神经纤维束进行的，这种神经纤维束被称为胼胝体。DCC基因突变的人表现出镜像运动障碍，有些人有严重的大脑缺陷，无法形成痂状体，但目前我们还不清楚该基因的功能。在这项研究中，我们将研究DCC在早期大脑发育中如何发挥作用，以调节穹隆体部的形成和镜像运动障碍。

The integration of information between the brain hemispheres occurs via a large bundle of connecting nerve fibres called the corpus callosum. People with a genetic mutation in DCC display mirror movement disorder and some have a severe brain defect where the corpus callosum fails to form, but at present we don’t understand the function of this gene. In this study we will investigate how DCC functions in early brain development to regulate corpus callosum formation and mirror movement disorder.