Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-? activity

哮喘和慢性阻塞性肺疾病（COPD）的特点是增强TGF？表达，其伴随着对复发性病毒和细菌感染的易感性。这种感染会加剧这些患者的肺部炎症，通常需要急诊科治疗。该项目提出，以澄清TGF？抑制剂，以减少病毒感染对COPD和哮喘患者的影响。

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by enhanced TGF? expression, which is accompanied by susceptibility to recurrent viral and bacterial infections. Such infections exacerbate lung inflammation in these patients, generally requiring emergency department treatment. This project proposes to clarify the therapeutic potential of TGF? inhibitors to reduce the impact of viral infections in patients with COPD and asthma.