Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-β activity

通过调节转化生长因子-β 活性减轻慢性炎症性疾病的严重感染

• 批准号: nhmrc : GNT1124485
• 负责人: Dr Michael Gantier
• 金额: $ 61.18万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/attenuating-severe-infections-factor-activity/1347412
• 关键词: Attenuating; severe; infections; chronic; inflammatory

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by enhanced TGFβ expression, which is accompanied by susceptibility to recurrent viral and bacterial infections. Such infections exacerbate lung inflammation in these patients, generally requiring emergency department treatment. This project proposes to clarify the therapeutic potential of TGFβ inhibitors to reduce the impact of viral infections in patients with COPD and asthma.

哮喘和慢性阻塞性肺疾病（COPD）的特征是TGFβ表达增强，伴有对复发性病毒和细菌感染的易感性。这种感染会加剧这些患者的肺部炎症，通常需要急诊科治疗。该项目旨在阐明TGFβ抑制剂在降低COPD和哮喘患者病毒感染影响方面的治疗潜力。