Attenuating severe infections in chronic inflammatory diseases through modulation of transforming growth factor-β activity

哮喘和慢性阻塞性肺疾病的特点是转化生长因子β表达增强，伴随着对反复发生的病毒和细菌感染的敏感性。这种感染加剧了这些患者的肺部炎症，通常需要急诊科治疗。该项目旨在阐明转化生长因子β抑制剂在降低慢性阻塞性肺疾病和哮喘患者病毒感染影响方面的治疗潜力。

Asthma and chronic obstructive pulmonary disease (COPD) are characterised by enhanced TGFβ expression, which is accompanied by susceptibility to recurrent viral and bacterial infections. Such infections exacerbate lung inflammation in these patients, generally requiring emergency department treatment. This project proposes to clarify the therapeutic potential of TGFβ inhibitors to reduce the impact of viral infections in patients with COPD and asthma.