inert atmosphere glove box for organometallic synthesis and catalysis

用于有机金属合成和催化的惰性气氛手套箱

• 批准号: 345667-2007
• 负责人: McNeil, Stephen
• 金额: $ 4.78万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=325916
• 关键词: inert; atmosphere; glove; box; organometallic

The majority of industrial chemical reactions and many synthetic transformations of organic compounds are carried out by transition-metal catalysts.  Changes in the arrangement of electrons at the catalytic metal centre have the potential to play a critical role in the efficiency and selectivity of these catalysts, so that understanding and exploiting the factors that control these properties can lead to the rational design of improved catalytic systems.  An integrated synthetic, mechanistic, and computational approach to probe the effects of electronic and geometric changes on the fundamental reactions of well-defined and isolated models for catalytic intermediates will afford valuable insights to guide the development of the next generation of designer catalysts.       The proposed chemical investigations involve the manipulation of highly air- and moisture-sensitive materials, so that the atmosphere in which the compounds are generated, isolated, and characterized must be rigorously free of both oxygen and water.  The simplest and most versatile means to do so is through the use of an inert-atmosphere glove box, an enclosed space filled with inert nitrogen gas and equipped with various accessories to allow for the storage, reaction, and isolation of highly sensitive chemical compounds.         The glove box system described in this proposal comes equipped with a number of accessories that make possible start-to-finish chemical manipulations.  A cold well and freezer allow for low-temperature reaction and isolation of chemical compounds.  A high-precision analytical balance is used for weighing of chemical reagents.  The atmospheric purity is maintained by continual passage of the interior atmosphere through a catalytic trap, and various antechambers permit the transport of materials into and out of the box.  Sensors give warning should the oxygen or moisture levels within the box exceed an acceptable threshold.  The result is an integrated system that makes possible all aspects of chemical synthesis inside a rigorously air- and moisture-free environment.

大多数工业化学反应和许多有机化合物的合成转化都是通过过渡金属催化剂进行的。  催化金属中心电子排列的变化有可能在这些催化剂的效率和选择性中发挥关键作用，因此了解和利用控制这些性能的因素可以导致改进催化系统的合理设计。  一种综合的合成、机械和计算方法来探讨电子和几何变化对催化中间体明确定义和孤立模型的基本反应的影响，将为指导下一代设计师催化剂的开发提供宝贵的见解。       拟议的化学研究涉及对空气和湿度高度敏感的材料的操作，因此化合物生成、分离和表征的大气必须严格不含氧气和水。  最简单、最通用的方法是使用惰性气氛手套箱，这是一个充满惰性氮气的封闭空间，并配备了各种附件，用于存储、反应和隔离高度敏感的化合物。         本提案中描述的手套箱系统配备了许多配件，可以实现从头到尾的化学操作。  冷井和冷冻机可以进行低温反应和化合物的分离。  化学试剂的称量采用高精度分析天平。  通过内部气氛持续通过催化捕集器来维持大气纯度，并且各种前室允许材料进出盒子。  如果盒子内的氧气或湿度水平超过可接受的阈值，传感器会发出警告。  其结果是一个集成系统，使得化学合成的各个方面都可以在严格的空气和湿气环境中进行。