Bisphosphonate Treatment of Childhood Femoral Head Avascular Necrosis due to Perthes Disease

珀尔特斯病（PD）发生于髋关节（股骨头）供血不足。这是一种严重的儿童疾病，澳大利亚每年有250多例新病例。PD导致通常圆形的股骨头变平和疼痛性关节炎。髋部变平是因为骨头被一种叫做破骨细胞的细胞吞噬。我们将测试一种旨在阻止这些破骨细胞的药物是否能防止髋关节变平。这将降低患关节炎的风险和髋关节置换术的需要。

Perthes disease (PD) occurs following loss of blood supply to the hip (femoral head). It is a severe childhood disorder with over 250 new cases per year in Australia. PD results in flattening of the normally round femoral head and painful arthritis. The hip becomes flat because the bone is eaten by cells called osteoclasts. We will test if a medicine aimed at stopping these osteoclasts can prevent hip flattening. This should decrease the risk of arthritis and the need for hip replacement.