Bisphosphonate Treatment of Childhood Femoral Head Avascular Necrosis due to Perthes Disease

双磷酸盐治疗 Perthes 病引起的儿童股骨头缺血性坏死

• 批准号: nhmrc : 632532
• 负责人: A/Pr Bruce Foster
• 金额: $ 91.23万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/bisphosphonate-treatment-childhood-perthes-disease/97308
• 关键词: Bisphosphonate; Treatment; Childhood; Femoral; Head

Perthes disease (PD) occurs following loss of blood supply to the hip (femoral head). It is a severe childhood disorder with over 250 new cases per year in Australia. PD results in flattening of the normally round femoral head and painful arthritis. The hip becomes flat because the bone is eaten by cells called osteoclasts. We will test if a medicine aimed at stopping these osteoclasts can prevent hip flattening. This should decrease the risk of arthritis and the need for hip replacement.

珀斯病(PD)是在失去髋部(股骨头)的血液供应后发生的。这是一种严重的儿童疾病，在澳大利亚每年有超过250例新病例。帕金森病会导致正常的圆形股骨头扁平和疼痛的关节炎。髋部变平是因为骨骼被称为破骨细胞的细胞吃掉。我们将测试一种旨在阻止这些破骨细胞的药物是否可以防止髋关节扁平。这应该会降低关节炎的风险和髋关节置换术的需要。