Cell-selective deletion of brain AT1A receptors in hypertension: Effect on blood pressure, increased ROS production and inflammation.

高血压患者大脑 AT1A 受体的细胞选择性缺失：对血压、ROS 产生增加和炎症的影响。

• 批准号: nhmrc : 1029396
• 负责人: Prof Andrew Allen
• 金额: $ 38.56万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/cell-selective-deletion-production-inflammation/110685
• 关键词: Cell; selective; deletion; brain; AT1A

Angiotensin is important for normal regulation of blood pressure but is also involved in cardiovascular diseases. Interruption of angiotensin’s actions is a common treatment of these diseases. Functional deletion of angiotensin receptors decreases blood pressure. Surprisingly the site(s) in the body responsible for this decrease are not known. We will examine the role of angiotensin receptors in the brain in the control of blood pressure in health and in cardiovascular disease.

血管紧张素对血压的正常调节很重要，但也参与心血管疾病。阻断血管紧张素的作用是治疗这些疾病的常用方法。血管紧张素受体的功能性缺失降低血压。令人惊讶的是，身体中负责这种减少的部位尚不清楚。我们将研究血管紧张素受体在大脑中的作用，在控制血压的健康和心血管疾病。